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Metallochemistry Of Neurodegeneration

por Kozlowski, Henryk ; Brown, David R. ; Valensin, Gianni

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Formato: Tapa dura (Hardcover)
Editorial: Springer Verlag
Año de Edición: 2006/11/09
Tema: SCIENCE / Chemistry / General
Tags: Neurodegenerative Diseases, physiopathology, Ions, adverse effects, Metals, Oxidative Stress, Proteins, physiology
Idioma: Inglés
Páginas: 281
Peso: 590.2 gramos
Estado: Nuevo
ISBN: 0854043608
ISBN 13: 9780854043606

Precio: US$ 283,29 Libro Disponible Despacho en 7 a 9 días hábiles Si lo compras hoy, lo recibirás entre el Miércoles 06 de Junio de 2012 y el Viernes 08 de Junio de 2012

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Resumen del libro

Publisher Summary 1

Bioinorganic chemistry has a cross disciplinary approach, applying the principles of chemistry to biological systems. Metallochemistry of Neurodegeneration: Biological, Chemical and Genetic Aspects discusses the rapidly developing area of metals in the nervous system and their role in neurodegenerative disease, such as Alzheimer's, Parkinson's and prion diseases. Written by leading experts in their fields, each chapter combines elements of genetics, biochemistry and biological inorganic chemistry in its discussion. The book highlights the differences in pathologies of neurodegenerative diseases but also discusses the mechanistic similarities. Sections include: metal ions and prion diseases; metal ions and Alzheimer disease; manganese in brain functioning; metal involvement in Parkinson disease; Cu-Zn superoxide dismutase and familial amyotrophic lateral sclerosis. This book will appeal to both chemists and biologists at the post graduate and research level.

Publisher Summary 2

This book will appeal to both chemists and biologists at the post graduate and research level.

Tabla de Contenidos del libro

Introduction

(11)

General Model for Protein Misfolding, Aggregation, Amyloid Formation and Neurodegeneration

(1)

Specificity of Molecular Mechanisms in Major Neurodegenerative Diseases

(6)

Alzheimer Disease (AD)

(1)

Parkinson Disease

(2)

Amyotrophic Lateral Sclerosis

(1)

Prions Diseases

(2)

Models of Amyloid Seeding in Neurodegenerative Diseases

(4)

References

(2)

Blood-Brain Barrier and Roots of Entry of Metal Ions into the Brain. Metal Ion Transport and Distribution in the Brain

(12)

General Features of Blood-Brain Barrier

(2)

Iron and Aluminium

(3)

Manganese

(2)

Lead and Mercury

(1)

The Olfactory Pathway of Metal Entry into the Brain

(1)

Astroglia and Metal Accumulation

(4)

References

(3)

Metal Ion-Induced Redox Reactions, Oxidative Stress and Possible Impact on Neurodegeneration

(15)

Metal Induced Production of ROS

(3)

Nitric Oxide

(2)

Oxidative Stress and Aging

(1)

ROS, Protein Oxidation and Aberrant Protein Interactions

(4)

Peroxidation of Lipids in Aging Brain

(1)

Impact of Oxidative Stress on DNA

(1)

ROS and Cell Death

(5)

References

(4)

Copper Metabolism in the Brain

(18)

Introduction

(1)

Models of Copper Metabolism

(4)

Mammalian Copper Homeostasis

(1)

Mammalian Cellular Copper Metabolism

(1)

Neurodegenerative Diseases and Copper

(1)

Wilson's and Menkes' Diseases

(5)

Familial Amyotrophic Lateral Sclerosis

(1)

Conclusions

(5)

References

(4)

Lithium, A Neuroprotective Element

(26)

IMPase

(10)

GSK-3

(12)

References

(3)

Neurotoxicity of Aluminium

(14)

Neurochemistry of Aluminum

(9)

Aluminum and the Etiology of Alzheimer's Disease

(5)

References

(3)

Manganese in the Brain Functioning

(20)

Introduction

(1)

Manganese Absorption

(1)

Manganese Transport to the Brain

(2)

Manganese Uptake in the Brain

101

(2)

Proteins that Utilise Manganese

103

(7)

Manganese Neurotoxicity

110

(1)

Effects on Brain Function

111

(1)

Neurological Disease Related to Manganese

111

(2)

Conclusions

113

(4)

References

113

(4)

Alzheimer's Disease: Which Metal Now?

117

(24)

Amyloid Precursor Protein

118

(2)

Cleavage of APP and Formation of β-Amyloid

120

(2)

Neurofibrillary Tangles

122

(1)

Copper, APP and Aβ

123

(2)

Metals and Alzheimer's Disease

125

(1)

A Balance Between Copper and Zinc

126

(3)

The Rise of Iron

129

(3)

Any More Metals in Alzheimer's Disease?

132

(1)

Coordination Chemistry of Metal Ions Interacting with APP

132

(9)

References

137

(4)

Prion Diseases and Redox Active Metals

141

(41)

Introduction

141

(6)

Cu-Binding to PrPc

147

(2)

Details of Cu2+ Co-Ordination to Mammalian PrPC and its Fragments

149

(6)

Binding of Cu2+ Ion by a Single Octapeptide Repeat Pro-His-Gly-Gly-Gly-Trp-Gly-Gln

149

(1)

pH-Dependence of Cu2+ Binding to Octapeptide Fragment

150

(1)

Binding of Cu2+ Ions to Dimeric and Tetrameric Octapeptide Fragments

151

(4)

The Fifth and Sixth Binding Sites Located in N-Terminal Domain

155

(1)

Binding of Cu2+ and Other Metals to PrP91-126 Region Cu(II) Coordination to PrP106-126 (KTNMKHMAGAAAAGAVVGGLG)

156

(4)

Involvement of His-96 in the Interaction of Cu(II) with the Neurotoxic Peptide Fragment

158

(1)

The Comparison of the Binding Abilities of Octameric and Neurotoxic Regions Toward Cu2+ Ions

158

(2)

Cu2+ Coordination to Chicken PrP

160

(2)

Copper Mediated PrP Internalization

162

(4)

Copper Transport

166

(1)

PrP as an Antioxidant

167

(3)

Manganese Binding

170

(1)

Cell Death and Metals

171

(3)

Direct Effects

172

(1)

Indirect Effects

173

(1)

Combined Effects

173

(1)

Age Effects

173

(1)

Metal Changes in TSEs

174

(2)

Copper and Mutant Prions

176

(1)

Conclusions

176

(6)

References

177

(5)

Are Metals Involved in Cu--Zn Superoxide Dismutase-Related Familial Amyotrophic Lateral Sclerosis

182

(19)

References

198

(3)

Parkinson's Disease: Any Role for Metals

201

(22)

Introduction

201

(1)

Cell Death in Parkinson's Disease

202

(1)

Genetics of Parkison's Disease

203

(2)

The Proteins Associated with Parkinson's Disease

205

(6)

Parkin

205

(2)

α-Synuclein

207

(4)

Metals in Parkinson's Disease

211

(2)

Bioinorganic Chemistry in Parkinson Disease

213

(1)

Binding of Copper Ions to α-Synuclein and its Fragments

214

(1)

Metal Ions and Catecholamines

214

(3)

The Neuromelanin of Substantia Nigra and Metal Ions

217

(1)

Conclusions

218

(5)

References

218

(5)

Chelating Agents in Metal Neurotoxicity

223

(21)

Copper

227

(3)

Lead

230

(2)

Mercury

232

(6)

Iron

238

(6)

References

242

(2)

Metal Complexes in the Brain Imaging and Diagnosis

244

(33)

Gadolinium Compounds

247

(2)

Monocrystalline Iron Oxide Nanocompounds

249

(2)

Delivery of MRI Contrast Agents

251

(12)

MRI Staining of the Hippocampal System

263

(3)

Contrast Agents in Stem Cells Therapy

266

(1)

Thallium Autometallography

267

(1)

Targeting of Contrast Agents to AD Amyloid Plaques

267

(10)

References

274

(3)

Subject Index

277

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